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Twenty-eight volunteers had skin biopsies (dorsal wrist) at baseline and at 6 months treatment for immunohistochemical assessment of fibrillin-1 (test product, n = 15 vehicle, n = 13). vehicle, n = 30 once daily for 6 months, face and hands) with clinical assessments performed at recruitment and following 1, 3 and 6 months of use. Sixty photoaged subjects were recruited to the RCT (test product, n = 30 vs. This observation infers potential to repair and perhaps clinically improve photoaged skin.Objective We examined another similar over-the-counter cosmetic ‘anti-ageing’ product using both the patch test assay and a 6-month double-blind, randomized controlled trial (RCT), with a further 6-month open phase to assess clinical efficacy in photoaged skin.Methods For the patch test, a commercially available test product and its vehicle were applied occluded for 12 days to photoaged forearm skin (n = 10) prior to biopsy and immunohistochemical assessment of fibrillin-1 all-trans retinoic acid (RA) was used as a positive control. Previously we have shown that application of a cosmetic ‘anti-ageing’ product to photoaged skin under occlusion for 12 days can stimulate the deposition of fibrillin-1. Summary Background Very few over-the-counter cosmetic ‘anti-ageing’ products have been subjected to a rigorous double-blind, vehicle-controlled trial of efficacy. Added workaround for hang when obtaining list of benchmark results. Added ECC support for additional Intel Skylake-SP chipset variants.Fixed hang due memory allocation issues for Intel Skylake/Kaby Lake chipsets.Added reporting of additional DDR5 SPD attributes.Fixed DIMM temperature read failure after reading SPD for certain DDR5 modules.Fixed incorrect CPU temperature reported for EPYC 7003 series chipsets due to temperature offsets.Fixed incorrect memory clock reported for AMD 19h 60-6fh chipsets.Fixed incorrect memory clock reported for Intel Alder Lake/Rocket Lake chipsets.
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